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Similarly, genetic mouse models deficient in any of the iron regulatory proteins, including HFE, hemojuvelin, hepcidin or Cp/Hp knockout mice also exhibit retinal iron accumulation with several features reminiscent of human AMD, such as sub-RPE deposits resembling drusen, lysosomal inclusions, and even subretinal neovascularization, recapitulating both dry and wet AMD phenotypes [111,112]

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24 FIGURE 4